K-Ras' Achilles' heel

Cancer's new Achilles' heel?

Claims to the discovery of cancers Achilles’ heel are multiple, even clichéd. Analogies to this Greek myth usually refer to the fall of the undefeatable, yet the novelty behind the legend is that a seemingly immortal foe could be toppled by something so innocuous as his heel. This may be the case for cancer and a non-coding mitochondrial RNA that as yet has no known physiological function or me...

Ideology: Criminology's Achilles' Heel?

The Achilles ’ Heel of CyberDefense

The Achilles' Heel of QBF

In recent years we have seen significant progress in the area of Boolean satisfiability (SAT) solving and its applications. As a new challenge, the community is now moving to investigate whether similar advances can be made in the use of Quantified Boolean Formulas (QBF). QBF provides a natural framework for capturing problem solving and planning in multiagent settings. However, contrarily to s...

ACHILLES and the Achilles Heel of Peripheral Vascular Intervention.

SEE PAGE 259 I n contrast to coronary artery disease in which a robust collection of data has demonstrated the merits of percutaneous revascularization, research investigating peripheral vascular intervention (PVI) has not yet matured in terms of magnitude, quality, or clarity. For example, only 1 randomized trial has assessed the efficacy of PVI relative to surgical bypass in patients with cri...